Recombinant Human Activin RIIA/ACVR2A Protein (Fc & His Tag)

Specifications

Catalog number

PKSH032039-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Abbreviation

Activin RIIA; ACVR2A

Synonyms

ACTR-IIA; ACTRIIA; ACVR2; ACVR2A; Activin Receptor Type IIA; Activin Receptor Type-2A

UniProt

P27037

Accession Number

P27037

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Ala20-Pro134

Applications

ELISA

Field of Research

Signal Transduction; Cancer; metabolism; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

41.2 kDa

Observed Molecular Weight

60kDa&40kDa

Species

Human