Recombinant Human Activin Receptor 2B/ACVR2B Protein (His Tag)

Specifications

Catalog number

PKSH032040-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD) ; a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.

Abbreviation

Activin Receptor 2B; ACVR2B

Synonyms

ACTR-IIB; ACVR2B; Activin Receptor Type IIB; Activin Receptor Type-2B; BMP Type II Receptor; BMP Type-2 Receptor; BMPR-2; Bone Morphogenetic Protein Receptor Type II; Bone Morphogenetic Protein Receptor Type-2

UniProt

Q13705

Accession Number

Q13705

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser19-Thr134

Field of Research

Signal Transduction; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.4 kDa

Observed Molecular Weight

25-38 kDa

Species

Human