Recombinant Human Adiponectin/ADIPOQ Protein (His Tag)

Specifications

Catalog number

PKSH032046-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.

Abbreviation

Adiponectin; ADIPOQ

Synonyms

30 kDa Adipocyte Complement-Related Protein; ACDC; ACRP3; ACRP30; ADIPOQ; Adipocyte; Adipocyte complement-related 30 kDa protein; Adiponectin; Adipose Most Abundant Gene Transcript 1 Protein; C1q and Collagen Domain-Containing Protein; Gelatin-Binding Protein; apM-1

UniProt

Q15848

Accession Number

Q15848

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu19-Asn244

Field of Research

Signal Transduction; Cardiovascular; Neuroscience; Cancer; metabolism; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25.6 kDa

Observed Molecular Weight

30 kDa

Species

Human