Recombinant Human ALDH1A2 Protein (His Tag)

Specifications

Catalog number

PKSH032053-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Aldehyde dehydrogenase 1 family member A2 (ALDH1A2), also known as retinaldehyde dehydrogenase 2 (RALDH2), belongs to the aldehyde dehydrogenase family which contains two members, the ALDH1 s (ALDH1A1, ALDH1A2 and ALDH1A3) and the 9-cis retinaldehyde dehydrogenase ALDH8 s. ALDH1A2 is key enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. RA is a paracrine hormone signaling molecule that functions in developing and adult tissues. ALDH1A2 was also found to regulate normal and tumor cell growth and differentiation. Several studies showed that ALDH1A2 expression is increased after the appearance of AraC resistance in clinical cases which means this protein is effective in AraC resistance.

Abbreviation

ALDH1A2

Synonyms

ALDH1A2; Aldehyde dehydrogenase family 1 member A2; RALDH (II) ; RALDH2; Retinal dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2

UniProt

O94788

Accession Number

O94788

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Ser518

Field of Research

Neuroscience; Developmental Biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

58.2 kDa

Observed Molecular Weight

50-65 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 20% Glycerol, pH 7.5.

Species

Human