Recombinant Human AKR1C2 Protein

Specifications

Catalog number

PKSH032054-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol) .

Abbreviation

AKR1C2

Synonyms

2-Dihydrobenzene-1;2-Diol Dehydrogenase;3-Alpha-HSD3; Aldo-Keto Reductase Family 1 Member C2; Chlordecone Reductase Homolog HAKRD; DD-2; DD/BABP; DD2; Dihydrodiol Dehydrogenase 2; Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein; Trans-1; Type III 3-Alpha-Hydro

UniProt

P52895

Accession Number

P52895

Expression System

E.coli

Tag

None

Sequence

Met 1-Tyr323

Field of Research

Signal Transduction; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

36.7 kDa

Observed Molecular Weight

35 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0.

Species

Human