Recombinant Human AKR1C3 Protein (His Tag)

Specifications

Catalog number

PKSH032055-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2, which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.

Abbreviation

AKR1C3

Synonyms

17-Beta-HSD 5;17-Beta-Hydroxysteroid Dehydrogenase Type 5;3-Alpha-HSD Type 2;3-Alpha-HSD Type II Brain;3-Alpha-Hydroxysteroid Dehydrogenase Type 2; Aldo-Keto Reductase Family 1 Member C3; Chlordecone Reductase Homolog HAKRb; DD-3; Dihydrodiol Dehydrogenase 3

UniProt

P42330

Accession Number

P42330

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Tyr323

Field of Research

Signal Transduction; Neuroscience; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.9 kDa

Observed Molecular Weight

38 kDa

Species

Human