Recombinant Human Amphiregulin/AREG Protein

Specifications

Catalog number

PKSH032063-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha (TGF-alpha) . As an EGF-related growth factor, AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. AREG may also play a protective role in Bleomycin-Induced Pneumopathy.

Abbreviation

Amphiregulin; AREG

Synonyms

AR; AREG; AREGB; Amphiregulin; CRDGF; Colorectum Cell-Derived Growth Factor; SDGF

UniProt

P15514

Accession Number

P15514

Expression System

E.coli

Tag

None

Sequence

Ser101-Lys198

Field of Research

Signal Transduction; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

11.4 kDa

Observed Molecular Weight

16 kDa

Species

Human