Recombinant Human ANGPTL8/β-trophin Protein (Fc Tag)

Specifications

Catalog number

PKSH032067-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proliferation is promising in diabetes therapy. Betatrophin treatment could supply or replace insulin injections by increasing the number of insulin-producing cells in diabetes.

Abbreviation

ANGPTL8; β-trophin

Synonyms

Angiopoietin-like protein 8; Angptl8; Betatrophin; Lipasin

UniProt

Q6UXH0

Accession Number

Q6UXH0

Expression System

HEK293 Cells

Tag

N-Fc

Sequence

Ala22-Ala198

Field of Research

Cell biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 80 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

46.0 kDa

Observed Molecular Weight

54 kDa

Species

Human