Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein

Specifications

Catalog number

PKSH032094-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED) -containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.

Abbreviation

PEA15

Synonyms

15 kDa Phosphoprotein Enriched in Astrocytes; Astrocytic Phosphoprotein PEA-15; PEA15; PED; Phosphoprotein Enriched in Diabetes

UniProt

Q15121

Accession Number

Q15121

Expression System

E.coli

Tag

None

Sequence

Met 1-Ala130

Field of Research

Cell biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

15.3 kDa

Observed Molecular Weight

12-16 kDa

Species

Human