Recombinant Human Survivin/BIRC5 Protein

Specifications

Catalog number

PKSH032109-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Baculoviral IAP Repeat-Containing Protein 5 (BIRC5) belongs to the IAP family. BIRC5 exists as a homodimer in the apo state and as a monomer in the CPC-bound state. BIRC5 contains one BIR repeat and is expressed only in fetal kidney and liver, and to lesser extent, lung and brain. BIRC5 functions as a multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. BIRC5 is also a component of a chromosome passage protein complex (CPC), which is essential for chromosome alignment and segregation during mitosis and cytokinesis. BIRC5 acts as an important regulator of the localization of this complex.

Abbreviation

Survivin; BIRC5

Synonyms

API4; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; BIRC5; Baculoviral IAP Repeat-Containing Protein 5; IAP4

UniProt

O15392

Accession Number

O15392

Expression System

E.coli

Tag

None

Sequence

Met 1-Asp142

Field of Research

Cell biology; Neuroscience; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

16.4 kDa

Observed Molecular Weight

16-18 kDa

Species

Human