Recombinant Human BAG2 Protein (His Tag)

Specifications

Catalog number

PKSH032114-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is a important component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex. In mammalian cells BAG1, BAG2, and BAG3 bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Abbreviation

BAG2

Synonyms

BAG Family Molecular Chaperone Regulator 2; BAG-2; BAG2; Bcl-2-Associated Athanogene 2

UniProt

O95816

Accession Number

O95816

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Asn211

Field of Research

Signal Transduction; Cell biology; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

25.9 kDa

Observed Molecular Weight

25-30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, 1mM DTT, 10% Glycerol, pH8.0.

Species

Human