Recombinant Human BMPR2 Protein (Fc & His Tag)

Specifications

Catalog number

PKSH032121-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.

Abbreviation

BMPR2

Synonyms

BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK

UniProt

Q13873

Accession Number

Q13873

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Ser27-Ile151

Field of Research

Signal Transduction; Cardiovascular; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

41.9 kDa

Observed Molecular Weight

60-70 kDa

Species

Human