Recombinant Human Butyrophilin 3A2/BTN3A2 Protein (His Tag)

Specifications

Catalog number

PKSH032133-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN) family and the immunoglobulin (IG) superfamily. Mature human BTN3A2 is a 305 amino acid (aa) glycoprotein. It contains a 219 aa extracellular region with one V-type Ig-like domain, and a 65 aa cytoplasmic tail. The cytoplasmic region undergoes phosphorylation on two serines. There are three potential splice forms. BTN3A2 is postulated to be expressed on immune-related cells, as it has a structural similarity to MHC and CD80/CD86 molecules. It plays a role in T-cell responses in the adaptive immune response and inhibits the release of IFNG from activated T-cells.

Abbreviation

Butyrophilin 3A2; BTN3A2

Synonyms

BT3.2; BTF3; BTF4; BTN3A2; Butyrophilin subfamily 3 member A2

UniProt

P78410

Accession Number

P78410

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln30-Trp248

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.6 kDa

Observed Molecular Weight

29 kDa

Species

Human