Recombinant Human C1qTNF1/CTRP1 Protein (His Tag)

Specifications

Catalog number

PKSH032134-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

C1QTNF1 is a secreted protein, contains 1 C1q domain and 1 collagen-like domain. C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. C1QTNF1 is a novel adipokine, providing a significant framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. C1QTNF1 increases the production of aldosterone. C1QTNF1 is vastly expressed in obese subjects as well as up-regulated in hypertensive patients, C1QTNF1 is identified molecular link between obesity and hypertension. C1QTNF1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.

Abbreviation

C1qTNF1; CTRP1

Synonyms

C1QTNF1; CTRP1; Complement C1q Tumor Necrosis Factor-Related Protein 1; G Protein-Coupled Receptor-Interacting Protein; GIP

UniProt

Q9BXJ1

Accession Number

Q9BXJ1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Arg26-Pro281

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

30.2 kDa

Observed Molecular Weight

37 kDa

Species

Human