Recombinant Human Cadherin-11/CDH11 Protein (Fc & His Tag)

Specifications

Catalog number

PKSH032137-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cadherin-11; also known as OSF-4; Osteoblast cadherin and CDH11; is a type II classical cadherin from the cadherin superfamily; integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells; may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular domain; a single membrane-spanning domain; and a small; highly conserved C-terminal cytoplasmic domain. It is shown that cadherin-11 is a viable molecular target for therapeutic intervention in Glioblastoma multiforme.

Abbreviation

Cadherin-11; CDH11

Synonyms

CDH11; Cadherin 11 Type 2 OB-Cadherin (Osteoblast) Isoform CRA_c; Cadherin 11 Type 2 OB-cadherin (Osteoblast)

UniProt

Q96CZ9

Accession Number

Q96CZ9

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Phe23-Thr617

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

93.6 kDa

Observed Molecular Weight

110 kDa

Species

Human