Recombinant Human Cadherin-3/CDH3 Protein (His Tag)

Specifications

Catalog number

PKSH032140-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cadherin-3 (CDH3) is a single-pass type I membrane protein that belongs to the cadherin superfamily. CDH3 is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. CDH3 is expressed in some normal epithelial tissues and in some carcinoma cell lines. CDH3 preferentially interacts with themselves in a homophilic manner in connecting cells. CDH3 is involved in loss of heterozygosity events in breast and prostate cancer. Mutations in CDH3 have been associated with congential hypotrichosis with juvenile macular dystrophy.

Abbreviation

Cadherin-3; CDH3

Synonyms

CDH3; CDHP; Cadherin-3; P-Cadherin; Placental Cadherin

UniProt

P22223

Accession Number

AAH41846.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu25-Gly654

Field of Research

Signal Transduction; Tags & Cell Markers; Neuroscience; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

70.4 kDa

Observed Molecular Weight

88-110 kDa

Species

Human