Recombinant Human Cadherin-6/CDH6 Protein (Fc Tag)

Specifications

Catalog number

PKSH032141-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 has high expression in kidney, brain, and cerebellum, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected in lung, pancreas, gastric mucosa and cytotrophoblasts. As a classic cadherin, Cadherin-6 will form homodimers and promote intercellular adhesion with itself and, possibly, Cadherin-9 and -14.

Abbreviation

Cadherin-6; CDH6

Synonyms

CDH6; Cadherin-6; K-Cadherin; KCAD; Kidney Cadherin

UniProt

P55285

Accession Number

P55285

Expression System

HEK293 Cells

Tag

C-Fc & C-Fc

Sequence

Thr19-Ala615&Ser54-Ala615

Field of Research

Signal Transduction; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

93.5 kDa (pro), 90 kDa (mature)

Observed Molecular Weight

110-130 kDa

Species

Human