Recombinant Human Calcitonin/CALCA Protein (His Tag, E. coli)

Specifications

Catalog number

PKSH032146-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Calcitonin is a secreted protein which belongs to the calcitonin family. Calcitonin is cleaved into the following two chains: Calcitonin and Katacalcin. Katacalcin is a potent plasma calcium-lowering peptide. Calcitonin is a 32-amino acid linear polypeptide hormone. Calcitonin acts to reduce blood calcium (Ca2+) ; opposing the effects of parathyroid hormone (PTH) . Its importance in humans has not been as well established as its importance in other animals; as its function is usually not significant in the regulation of normal calcium homeostasis. Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Abbreviation

Calcitonin; CALCA

Synonyms

CALC1; CALCA; CCP; Calcitonin; Calcitonin Carboxyl-Terminal Peptide; Katacalcin; PDN-21

UniProt

P01258

Accession Number

P01258

Expression System

E.coli

Tag

C-His

Sequence

Tyr58-Asn141

Field of Research

Signal Transduction; Cardiovascular; Neuroscience; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

10.5 kDa

Observed Molecular Weight

14-20 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 50% Glycerol, pH 7.4.

Species

Human