Recombinant Human Cardiotrophin-1/CTF1 Protein (His Tag)

Specifications

Catalog number

PKSH032175-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130) /leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.

Abbreviation

Cardiotrophin-1; CTF1

Synonyms

CT-1; CTF1; Cardiotrophin-1

UniProt

Q16619

Accession Number

Q16619

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Ala201

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

22.6 kDa

Observed Molecular Weight

25 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, 2mM EDTA, 5% Trehalose, pH 7.4.

Species

Human