Recombinant Human Cathepsin D/CTSD Protein (His Tag)

Specifications

Catalog number

PKSH032180-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein acid protease active in intracellular protein breakdown and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. It is specificity similar to; but narrower than; that of pepsin A and it does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. It consists of a light chain and a heavy chain and expressed in the aorta extrcellular space. The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%) . Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.It belongs to the peptidase A1 family

Abbreviation

Cathepsin D; CTSD

Synonyms

CLN10; CPSD; CTSD; Cathepsin D; HEL-S-130P

UniProt

P07339

Accession Number

P07339

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu21-Leu412

Field of Research

Signal Transduction; Cell biology; Neuroscience; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

43.6 kDa

Observed Molecular Weight

50 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.

Species

Human