Recombinant Human Cathepsin L/CTSL Protein (His Tag)

Specifications

Catalog number

PKSH032182-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tumor invasion and metastasis, bone resorption, and turnover of intracellular and secreted proteins involved in growth regulation. Unlike the precursor forms of other papain family members, the 43 kDa pro-cathepsin L itself is secreted from various cells. Pro-cathepsin L is the major excreted protein of malignantly transformed mouse fibroblasts and is also one of the major acidic cysteine proteases in mammalian cells.

Abbreviation

Cathepsin L; CTSL

Synonyms

CTSL; CTSL1; Cathepsin L1; MEP; Major Excreted Protein

UniProt

P07711

Accession Number

AAH12612

Expression System

HEK293 Cells

Tag

C-His

Sequence

Thr18-Val333

Field of Research

Signal Transduction; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

36.9 kDa

Observed Molecular Weight

34 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.5.

Species

Human