Recombinant Human CCL3 Protein

Specifications

Catalog number

PKSH032197-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits chemoattractive and adhesive effects on lymphocytes. CCL3 exerts multiple effects on hematopoietic precursor cells and inhibits the proliferation of hematopoietic stem cells in vitro as well as in vivo. CCR1 and CCR5 have been identified as functional receptors for CCL3.

Abbreviation

CCL3

Synonyms

C-C Motif Chemokine 3; CCL3; G0/G1 Switch Regulatory Protein 19-1; G0S19-1; MIP-1-Alpha; MIP1A; Macrophage Inflammatory Protein 1-Alpha; PAT 464.1; SCYA3; SIS-Beta; Small-Inducible Cytokine A3; Tonsillar Lymphocyte LD78 Alpha Protein

UniProt

P10147

Accession Number

P10147

Expression System

E.coli

Tag

None

Sequence

Ala 27-Ala 92

Applications

Cell culture

Field of Research

Immunology

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Measure by its ability to chemoattract human PBMC using a concentration range of 5 -50 ng/mL.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

8.4 kDa

Observed Molecular Weight

8-11 kDa

Species

Human