Recombinant Human CCL3L1 Protein (His Tag)

Specifications

Catalog number

PKSH032198-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-C Motif Chemokine 3-Like 1 (CCL3L1) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. CCL3L1 is a ligand for CCR1, CCR3 and CCR5. CCL3L1 binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5) . CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The processed form LD78-beta (3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. The copy number of this gene varies among individuals: most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more centromeric full-length gene.

Abbreviation

CCL3L1

Synonyms

C-C Motif Chemokine 3-Like 1; CCL3L1; CCL3L3; D17S1718; G0/G1 Switch Regulatory Protein 19-2; G0S19-2; LD78-Beta (1-70) ; PAT 464.2; SCYA3L1; Small-Inducible Cytokine A3-Like 1; Tonsillar Lymphocyte LD78 Beta Protein

UniProt

P16619

Accession Number

P16619

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala24-Ala93

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

8.8 kDa

Observed Molecular Weight

18 kDa

Species

Human