Recombinant Human CD200R1 Protein (Fc Tag)

Specifications

Catalog number

PKSH032207-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytoplasmic ITIM (immunoreceptor tyrosinebased inhibitory motif) . The receptor-substrate interaction may function as a myeloid downregulatory signal.

Abbreviation

CD200R1

Synonyms

CD200 Cell Surface Glycoprotein Receptor; CD200R; CD200R1; CRTR2; Cell Surface Glycoprotein CD200 Receptor 1; Cell Surface Glycoprotein OX2 Receptor 1; MOX2R; OX2R

UniProt

Q8TD46

Accession Number

Q8TD46

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ala27-Leu266

Field of Research

Microbiology; Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

53.9 kDa

Observed Molecular Weight

70-105 kDa

Species

Human