Recombinant Human CD44 Protein (Fc Tag)

Specifications

Catalog number

PKSH032219-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands; such as osteopontin; collagens; and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore; an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium; stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.

Abbreviation

CD44

Synonyms

CDW44; CSPG8; ECMR-III; Epican; Extracellular Matrix Receptor III; GP90 Lymphocyte Homing/Adhesion Receptor; HCELL; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate Receptor; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; Phagocytic Glycoprotein

UniProt

P16070

Accession Number

P16070

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln21-Pro220

Field of Research

Cancer; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

49.2 kDa

Observed Molecular Weight

75-95 kDa

Species

Human