Recombinant Human CD55/DAF Protein (His Tag)

Specifications

Catalog number

PKSH032222-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD55 is a member of the RCA (regulators of complement activation) family. RCA proteins is characterized by the presence of four to 30 SCRs (short consensus repeats also called CCPs for control protein modules) in their plasmaexposed regions. CD55 containing four SCR modules is involved in the regulation of the complement cascade. CD55 is known to bind CD97 via the first SCR. It also binds physiologically generated C3 convertases with its second and third SCRs. Binding results in an accelerated “decay”, or dissociation of active C3 convertases, thus blocking the development of C’ attack complexes on nonforeign cells. It is known that viruses and bacteria also utilize multiple SCR sites for infection.

Abbreviation

CD55; DAF

Synonyms

CD55; CR; CROM; Complement Decay-Accelerating factor; DAF; TC

UniProt

P08174

Accession Number

P08174

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asp35-Ser353

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.0 kDa

Observed Molecular Weight

50-75 kDa

Species

Human