Recombinant Human CDK2AP2 Protein (Human Cells, His Tag)

Specifications

Catalog number

PKSH032232-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CDK2AP2; also known as DOC1R; is short for cyclin-dependent kinase 2-associated protein 2. The gene CDK2AP2 encodes this protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. It belongs to the CDK2AP family. CDK2AP1 (cyclin-dependent kinase 2-associated protein 1) ; corresponding to the gene doc-1 (deleted in oral cancer 1) ; is a tumor suppressor protein. The doc-1 gene is absent or down-regulated in hamster oral cancer cells and in many other cancer cell types. The ubiquitously expressed CDK2AP1 protein is the only known specific inhibitor of CDK2; making it an important component of cell cycle regulation during G (1) -to-S phase transition.

Abbreviation

CDK2AP2

Synonyms

CDK2-associated protein 2; CDK2AP2; Cyclin-dependent kinase 2-associated protein 2; DOC-1-related protein; DOC-1R; DOC1R; p14

UniProt

O75956

Accession Number

O75956

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Thr126

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.1 kDa

Observed Molecular Weight

26 kDa

Species

Human