Recombinant Human CEACAM5/CEA Protein (His Tag)

Specifications

Catalog number

PKSH032236-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition. CEACAM5; also called CEA and CD66e; is characterized by having seven extracellular Ig domains and a glycosylphosphatidylinositol (GPI) anchor. CEACAM5 is expressed primarily by epithelial cells; and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM1. Studies have shown that CEACAM5 is overexpressed in a majority of carcinomas; and its overexpression can protect tumor cells from apoptosis. It is commonly used as a cancer marker.

Abbreviation

CEACAM5; CEA

Synonyms

CD66e; CEA; CEACAM5; Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 5; Meconium antigen 100

UniProt

P06731

Accession Number

NP_004354.3

Expression System

HEK293 Cells

Tag

C-His

Sequence

Lys35-Ala685

Field of Research

Tags & Cell Markers; Microbiology; Cancer; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

72.4 kDa

Observed Molecular Weight

95-150 kDa

Citation 01

https://link.springer.com/content/pdf/10.1007/s00604-019-3281-4.pdf

Species

Human