Recombinant Human CEACAM8/CD66b Protein (His Tag)

Specifications

Catalog number

PKSH032239-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 (CEACAM8) is a single chain, GPI-anchored, highly glycosylated protein which belongs to the immunoglobulin superfamily and the carcinoembryonic antigen (CEA) family. CEACAM8 is expressed by neutrophils and eosinophils, and serves as a binding partner for CEACAM-6 and Galectin-3. It contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. Mature human CEACAM8 is a 287 amino acid GPI-linked glycoprotein. CEACAM family members are a set of widely expressed proteins involved in several biological functions, including cell adhesion, migration, signal transduction, and the regulation of gene expression. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells.

Abbreviation

CEACAM8; CD66b

Synonyms

CD66b; CD67 Antigen; CEACAM8; CGM6; Carcinoembryonic Antigen CGM6; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8; Non-Specific Cross-Reacting Antigen NCA-95

UniProt

P31997

Accession Number

P31997

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln35-His141

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

13.0 kDa

Observed Molecular Weight

17-25 kDa

Species

Human