Recombinant Human CLEC10A/CD301 Protein (His Tag)

Specifications

Catalog number

PKSH032256-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc) . Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.

Abbreviation

CLEC10A; CD301

Synonyms

C-Type Lectin Domain Family 10 Member A; C-Type Lectin Superfamily Member 14; CD301; CLEC10A; CLECSF13; CLECSF14; HML; Macrophage Lectin 2

UniProt

Q8IUN9

Accession Number

Q8IUN9

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln61-His316

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

29.8 kDa

Observed Molecular Weight

40 kDa

Species

Human