Recombinant Human CLEC4E/Mincel Protein (His Tag)

Specifications

Catalog number

PKSH032258-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-Type Lectin Domain Family 4 Member E (CLEC4E) is a 219 amino acid single-pass type II membrane protein that contains one C-type Lectin domain. It is expressed in monocytes, CLEC4E functions as a downstream target of C/EBP β and is thought to play a role in the inflammatory response, possibly via transcriptional control of C/EBP β. CLEC4E may play a role in the response to inflammatory stimuli in peritoneal macrophages and may be involved in immune surveillance processes under transcriptional control of CEBPB. Human CLEC4E shares 67% sequence identity with its mouse counterpart, suggesting a similar function between species. CLEC-4E exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to a natural killer gene complex region on human chromosome 12.

Abbreviation

CLEC4E; Mincel

Synonyms

C-Type Lectin Domain Family 4 Member E; C-Type Lectin Superfamily Member 9; CLEC4E; CLECSF9; MINCLE; Macrophage-Inducible C-Type Lectin

UniProt

Q9ULY5

Accession Number

Q9ULY5

Expression System

HEK293 Cells

Tag

C-His

Sequence

Arg41-Leu219

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

21.7 kDa

Observed Molecular Weight

26 kDa

Species

Human