Recombinant Human COL8A1 Protein (His Tag)

Specifications

Catalog number

PKSH032267-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Collagen alpha-1 (VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2 (VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium of large blood vessels. The expression level can be up-regulated during vascular injury, in atherosclerosis and in diabetes. COL8A1 may have a role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

Abbreviation

COL8A1

Synonyms

C3orf7; COL8A1; Collagen Alpha-1 (VIII) Chain; Endothelial Collagen; Vastatin

UniProt

P27658

Accession Number

P27658

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gly28-Met744

Field of Research

Signal Transduction; Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

71.6 kDa

Observed Molecular Weight

58&85 kDa

Species

Human