Recombinant Human Complement Factor B/CFB Protein (His Tag)

Specifications

Catalog number

PKSH032272-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Complement Factor B (CFB) belongs to the peptidase S1 family of enzymes. It is expressed by hepatocytes and macrophages and localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. CFB which is a component of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.

Abbreviation

Complement Factor B; CFB

Synonyms

BF; BFD; C3/C5 Convertase; CFB; Complement Factor B; GBG; Glycine-Rich Beta Glycoprotein; PBF2; Properdin Factor B

UniProt

P00751

Accession Number

AAH04143.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Thr 26-Leu764

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

84.1 kDa

Observed Molecular Weight

90-120 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Species

Human