Recombinant Human CFHR5 Protein (His Tag)

Specifications

Catalog number

PKSH032274-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Complement factor H-related protein 5 (FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other complement components, suggesting that FHR-5 may play a role in complement activation and regulation. Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

Abbreviation

CFHR5

Synonyms

CFHL5; CFHR5; Complement factor H-related protein 5; FHR5

UniProt

Q9BXR6

Accession Number

Q9BXR6

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu19-Glu569

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

63.5 kDa

Observed Molecular Weight

61 kDa

Species

Human