Recombinant Human Contactin 2/CNTN2 Protein (His Tag)

Specifications

Catalog number

PKSH032278-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Contactin-2 (CNTN2) is encoded by the CNTN2 gene, which belongs to the immunoglobulin superfamily and contactin family. It contains 4 fibronectin type-III domains and 6 Ig-like C2-type domains. It is a glycosylphosphatidylinositol (GPI) -anchored neuronal membrane protein that functions as a cell adhesion molecule. CNTN2 may play a role in the formation of axon connections in the developing nervous system. In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.

Abbreviation

Contactin 2; CNTN2

Synonyms

AXT; Axonal glycoprotein TAG-1; Axonin-1; CNTN2; Contactin-2; TAG1; TAX1; Transient axonal glycoprotein 1

UniProt

Q02246

Accession Number

Q02246

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser31-Asn1012

Field of Research

Neuroscience; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

108.5 kDa

Observed Molecular Weight

110-140 kDa

Species

Human