Recombinant Human CTHRC1 Protein (His Tag)

Specifications

Catalog number

PKSH032288-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Collagen triple helix repeat-containing protein 1 is a protein that in humans is encoded by the CTHRC1 gene. It acts as a negative regulator of collagen matrix deposition. It may cause the disease of Barrett esophagus . Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

Abbreviation

CTHRC1

Synonyms

CTHRC1; Collagen triple helix repeat-containing protein 1; Protein NMTC1

UniProt

Q96CG8

Accession Number

Q96CG8

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser31-Lys243

Field of Research

Signal Transduction; Cardiovascular; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.1 kDa

Observed Molecular Weight

25-30 kDa

Species

Human