Recombinant Human DCUN1D1 Protein (His Tag)

Specifications

Catalog number

PKSH032344-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

DCN1-Like Protein 1 is a protein containing 1 DCUN1 domain and 1 UBA-like domain. DCN1-Like Protein 1 contains part of an E3 Ubiquitin Ligase Complex for Neddylation. It is required for Neddylation of Cullin components of E3 Cullin-RING Ubiquitin Ligase complexes. It enhances the rate of Cullins Neddylation. DCN1-Like Protein 1 recruits the NEDD8-charged E2 Enzyme to the Cullin component. DCUN1D1 is involved in the release of inhibitory effects of CAND1 on the Cullin-RING Ligase E3 complex assembly and activity. It acts also as an oncogene facilitating malignant transformation and carcinogenic progression.

Abbreviation

DCUN1D1

Synonyms

DCN1-Like Protein 1; DCUN1 Domain-Containing Protein 1; DCUN1D1; DCUN1L1; Defective in Cullin Neddylation Protein 1-Like Protein 1; RP42; SCCRO; Squamous Cell Carcinoma-Related Oncogene

UniProt

Q96GG9

Accession Number

Q96GG9

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Val259

Field of Research

Cell biology; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

32.3 kDa

Observed Molecular Weight

32 kDa

Species

Human