Recombinant Human DR6/TNFRSF21 Protein (Fc Tag)

Specifications

Catalog number

PKSH032346-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) . DR6 is also expressed on the tumor cell lines and can be induced by TNF-α.

Abbreviation

DR6; TNFRSF21

Synonyms

CD358; DR6; Death Receptor 6; TNFRSF21; Tumor Necrosis Factor Receptor Superfamily Member 21

UniProt

O75509

Accession Number

O75509

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln42-Leu350

Field of Research

Cell biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

61.7 kDa

Observed Molecular Weight

80-90 kDa

Species

Human