Recombinant Human DKK3 Protein (His Tag)

Specifications

Catalog number

PKSH032354-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Dickkopf-related protein 3 (DKK3) belongs to the DKK protein family including Dkk-1, 2, 3 and -4. DKK3 is a 350 amino acid secreted glycoprotein which is comprised of an N-terminal signal peptide and 2 conserved cysteine-rich domains that are separated by a 12 amino acid linker region. Dkk-3 also have one prokineticin domain. DKK3 is involved in embryonic development through its inhibition of the WNT signaling pathway. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.

Abbreviation

DKK3

Synonyms

DKK3; Dickkopf-3; Dickkopf-Related Protein 3; Dkk-3; REIC; hDkk-3

UniProt

Q9UBP4

Accession Number

Q9UBP4

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala22-Ile350

Field of Research

Signal Transduction; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.2 kDa

Observed Molecular Weight

73 kDa

Species

Human