Recombinant Human Dipeptidase 1/DPEP1 Protein (His Tag)

Specifications

Catalog number

PKSH032356-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Dipeptidase 1 (DPEP1) is a kidney membrane enzyme that belongs to the peptidase M19 family. DPEP1 is a homodimer and is inhibited by L-penicillamine. DPEP1 hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates. DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics; such as penem and carbapenem. DPEP1 may play an important role in the regulation of leukotriene activity. DPEP1 expression in cancer is significantly higher than that in normal tissue. However; DPEP1 expression decreased with pathological differentiation; lymph-node and distant metastasis.

Abbreviation

Dipeptidase 1; DPEP1

Synonyms

DPEP1; Dehydropeptidase-I; Dipeptidase 1; MBD1; MDP; Microsomal Dipeptidase; RDP; Renal Dipeptidase; hRDP

UniProt

P16444

Accession Number

P16444

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asp17-Ser385

Field of Research

Cell biology; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

42.1 kDa

Observed Molecular Weight

41 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.

Species

Human