Recombinant Human MAN1B1 Protein (His Tag)

Specifications

Catalog number

PKSH032400-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15) . Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

Abbreviation

MAN1B1

Synonyms

2-Alpha-Mannosidase;2-Mannosidase; ER Alpha-1; ER Mannosidase 1; ERMan1; Endoplasmic Reticulum Mannosyl-Oligosaccharide 1; MAN1B1; Man9GlcNAc2-Specific-Processing Alpha-Mannosidase; Mannosidase Alpha Class 1B Member 1

UniProt

Q9UKM7

Accession Number

Q9UKM7

Expression System

HEK293 Cells

Tag

C-His

Sequence

Asp106-Ala699

Field of Research

Tags & Cell Markers

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

68.7 kDa

Observed Molecular Weight

58-80 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl,10mM reduced Glutathione, pH 8.0.

Species

Human