Recombinant Human FAS/TNFRSF6 Protein (Fc Tag)

Specifications

Catalog number

PKSH032413-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

FAS (TNFRSF6) is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Abbreviation

FAS; TNFRSF6

Synonyms

APT1; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FAS1; FASLG receptor; TNFRSF6 and FAS; Tumor necrosis factor receptor superfamily member 6

UniProt

P25445

Accession Number

P25445

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln26-Asn173

Field of Research

Cell biology; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

44.6 kDa

Observed Molecular Weight

60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Species

Human