Recombinant Human FcRn & B2M Heterodimer Protein (His Tag)

Specifications

Catalog number

PKSH032422-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51 (alpha chain) and Beta-2-microglobulin (Beta chain) . The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk, Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog (FcRn) and beta-2-microglobulin (B2M) .

Abbreviation

FcRn & B2M Heterodimer

Synonyms

FCRN; IgG receptor FcRn; Neonatal Fc receptor

UniProt

P55899; P61769

Accession Number

AAF72596&P61769

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala24-Leu290&Ile21-Met 119

Field of Research

Cardiovascular; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

31.2&11.7 kDa

Observed Molecular Weight

13&37 kDa

Species

Human