Recombinant Human FGF-19/FGF19 Protein (His Tag)

Specifications

Catalog number

PKSH032436-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs) : FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure.

Abbreviation

FGF-19; FGF19

Synonyms

FGF-19; FGF19; Fibroblast growth factor 19

UniProt

O95750

Accession Number

O95750

Expression System

E.coli

Tag

C-His

Sequence

Phe27-Lys216

Applications

Cell culture

Field of Research

Signal Transduction; Neuroscience; Cancer; Stem cells

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

22.6 kDa

Observed Molecular Weight

24 kDa

Species

Human