Recombinant Human FLT3LG/Flt3 Ligand Protein (His Tag)

Specifications

Catalog number

PKSH032452-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fms-Related Tyrosine Kinase 3 Ligand (FLT3LG) is a hematopoietic four helical bundle cytokine. Mature human Flt-3 Ligand consists of a extracellular domain (ECD) with a cytokine-like domain and a juxtamembrane tether region, a transmembrane segment, and a cytoplasmic tail. Human and mouse Flt-3 Ligand show cross-species activity. Flt-3 Ligand is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts.It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1) . In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors by activiation of Flt 3 receptor.

Abbreviation

FLT3LG; Flt3 Ligand

Synonyms

FLT3LG; Flt3 Ligand; Flt3L; Fms-Felated Tyrosine Kinase 3 Ligand; SL Cytokine

UniProt

P49771

Accession Number

P49771

Expression System

HEK293 Cells

Tag

C-His

Sequence

Thr 27-Pro184

Field of Research

Cardiovascular; immunology

Endotoxin

< 0.01 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

19.0 kDa

Observed Molecular Weight

24-32 kDa

Species

Human