Recombinant Human GABA Protein (His & FcTag)

Specifications

Catalog number

PKSH032465-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development; differentiation; growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter; GABA; acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA (A) receptors and its interaction with the cytoskeleton.

Abbreviation

GABA

Synonyms

GABA (A) Receptor-Associated Protein; GABARAP; GABARAP Protein; HCG1987397 Isoform CRA_b

UniProt

Q6IAW1

Accession Number

Q6IAW1

Expression System

E.coli

Tag

N-His & C-Fc

Sequence

Met1-Leu117

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

43.2 kDa

Observed Molecular Weight

50 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 20% Glycerol, pH 7.0.

Species

Human