Recombinant Human Gankyrin/PSDM10 Protein

Specifications

Catalog number

PKSH032479-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.

Abbreviation

Gankyrin; PSDM10

Synonyms

26S Proteasome Non-ATPase Regulatory Subunit 10;26S Proteasome Regulatory Subunit p28; Gankyrin; PSMD10; p28 (GANK)

UniProt

O75832

Accession Number

O75832

Expression System

E.coli

Tag

None

Sequence

Met 1-Gly226

Field of Research

Cell biology; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

24.4 kDa

Observed Molecular Weight

26 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.

Species

Human