Recombinant Human Glucagon/GCG Protein (His Tag)

Specifications

Catalog number

PKSH032491-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.

Abbreviation

Glucagon; GCG

Synonyms

GCG; GLP-1; GLP-2; GRPP; Glicentin; Glicentin-Related Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-like Peptide 1; Incretin Hormone; OXM; OXY; Oxyntomodulin

UniProt

P01275

Accession Number

P01275

Expression System

HEK293 Cells

Tag

C-His

Sequence

Arg21-Lys180

Field of Research

Signal Transduction; Cancer; Developmental Biology; metabolism; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

18.6 kDa

Observed Molecular Weight

19 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 50% Glycerol, pH 8.0.

Species

Human