Recombinant Human GDF11/BMP-11 Protein

Specifications

Catalog number

PKSH032511-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Growth/differentiation factor 11 (GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.

Abbreviation

GDF11; BMP-11

Synonyms

BMP-11; Bone morphogenetic protein 11; GDF-11; Growth/differentiation factor 11

UniProt

O95390

Accession Number

O95390

Expression System

HEK293 Cells

Tag

None

Sequence

Asn299-Ser407

Field of Research

Signal Transduction; Cell biology; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

12.5 kDa

Observed Molecular Weight

13-20 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50% glycerol, pH 7.4.

Species

Human