Recombinant Human HSPB8 Protein (His Tag)

Specifications

Catalog number

PKSH032525-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in the cytoplasm and nucleus. HSPB8 usually exists in monomer, it can interact with HSPB1 and DNAJB6. HSPB8 displays temperature-dependent chaperone activity, appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Abbreviation

HSPB8

Synonyms

Alpha-crystallin C chain; CRYAC; E2-induced gene 1 protein; E2IG1; HSP22; HSPB8; Heat shock protein beta-8; HspB8; Protein kinase H11; Small stress protein-like protein HSP22

UniProt

Q9UJY1

Accession Number

Q9UJY1

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Thr196

Field of Research

Signal Transduction; Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

22.7 kDa

Observed Molecular Weight

23 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5mM EDTA, pH 7.4.

Species

Human